Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: An experimental rat model study
No Thumbnail Available
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The aim of our study is to investigate the effect of sunitinib on diabetes mellitus related-ovarian injury and fibrosis in rat models. An experimental diabetes mellitus model was created in 16 rats, and eight rats with normal blood glucose levels were included in control group (Group-1). The diabetic rats were divided into two groups:diabetic control group (water given)-Group-2 and sunitinib treatment group-Group-3. After four weeks, bilateral oophorectomy was performed and ovaries were examined histologically. The groups were compared by Student's t-test, analysis of variance (ANOVA) and Mann-Whitney's U-test. There was a significant increase in no-medication (water given) diabetic rat's ovary (Group-2) in terms of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappaB immune-expression compared with control group normal rats' ovary (Group-1) (p < 0.0001). Stromal degeneration (p = 0.04), stromal fibrosis (p = 0.01), follicular degeneration (p = 0.02), NF-kappaB immune-expression (p = 0.001) significantly decreased in sunitinib-treated diabetic rat's ovary (Group-3) when compared with no-medication (water given) diabetic rat's ovary (Group-2) (p < 0.05). When we used sunitinib in the treatment of diabetic rats, ovarian injury, fibrosis and NF-kappaB immunoexpression decreased significantly. The effects of sunitinib in rat models give hope to the improved treatment of premature ovarian failure due to diabetes mellitus in humans. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
Description
Keywords
Angiogenesis Inhibitors , Animals , Diabetes Mellitus, Experimental , Disease Models, Animal , Female , Fibrosis , Immunohistochemistry , Indoles , NF-kappa B , Ovary , Primary Ovarian Insufficiency , Pyrroles , Rats , glucose , immunoglobulin enhancer binding protein , sunitinib , angiogenesis inhibitor , immunoglobulin enhancer binding protein , indole derivative , pyrrole derivative , sunitinib , animal experiment , animal model , animal tissue , Article , controlled study , drug effect , drug mechanism , experimental diabetes mellitus , female , fibrosis , glucose blood level , histopathology , nonhuman , ovariectomy , ovary disease , ovary follicle , premature ovarian failure , priority journal , protein expression , rat , tissue degeneration , animal , complication , disease model , drug effects , experimental diabetes mellitus , immunohistochemistry , metabolism , ovary , pathology , Primary Ovarian Insufficiency