Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: An experimental rat model study

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dc.contributor.authorErbas O.
dc.contributor.authorPala H.G.
dc.contributor.authorPala E.E.
dc.contributor.authorArtunc Ulkumen B.
dc.contributor.authorAkman L.
dc.contributor.authorAkman T.
dc.contributor.authorOltulu F.
dc.contributor.authorAktug H.
dc.contributor.authorYavasoglu A.
dc.date.accessioned2024-07-22T08:13:27Z
dc.date.available2024-07-22T08:13:27Z
dc.date.issued2015
dc.description.abstractThe aim of our study is to investigate the effect of sunitinib on diabetes mellitus related-ovarian injury and fibrosis in rat models. An experimental diabetes mellitus model was created in 16 rats, and eight rats with normal blood glucose levels were included in control group (Group-1). The diabetic rats were divided into two groups:diabetic control group (water given)-Group-2 and sunitinib treatment group-Group-3. After four weeks, bilateral oophorectomy was performed and ovaries were examined histologically. The groups were compared by Student's t-test, analysis of variance (ANOVA) and Mann-Whitney's U-test. There was a significant increase in no-medication (water given) diabetic rat's ovary (Group-2) in terms of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappaB immune-expression compared with control group normal rats' ovary (Group-1) (p < 0.0001). Stromal degeneration (p = 0.04), stromal fibrosis (p = 0.01), follicular degeneration (p = 0.02), NF-kappaB immune-expression (p = 0.001) significantly decreased in sunitinib-treated diabetic rat's ovary (Group-3) when compared with no-medication (water given) diabetic rat's ovary (Group-2) (p < 0.05). When we used sunitinib in the treatment of diabetic rats, ovarian injury, fibrosis and NF-kappaB immunoexpression decreased significantly. The effects of sunitinib in rat models give hope to the improved treatment of premature ovarian failure due to diabetes mellitus in humans. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
dc.identifier.DOI-ID10.3109/09513590.2015.1005593
dc.identifier.issn09513590
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16344
dc.language.isoEnglish
dc.publisherInforma Healthcare
dc.subjectAngiogenesis Inhibitors
dc.subjectAnimals
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectFibrosis
dc.subjectImmunohistochemistry
dc.subjectIndoles
dc.subjectNF-kappa B
dc.subjectOvary
dc.subjectPrimary Ovarian Insufficiency
dc.subjectPyrroles
dc.subjectRats
dc.subjectglucose
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectsunitinib
dc.subjectangiogenesis inhibitor
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectindole derivative
dc.subjectpyrrole derivative
dc.subjectsunitinib
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjectexperimental diabetes mellitus
dc.subjectfemale
dc.subjectfibrosis
dc.subjectglucose blood level
dc.subjecthistopathology
dc.subjectnonhuman
dc.subjectovariectomy
dc.subjectovary disease
dc.subjectovary follicle
dc.subjectpremature ovarian failure
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrat
dc.subjecttissue degeneration
dc.subjectanimal
dc.subjectcomplication
dc.subjectdisease model
dc.subjectdrug effects
dc.subjectexperimental diabetes mellitus
dc.subjectimmunohistochemistry
dc.subjectmetabolism
dc.subjectovary
dc.subjectpathology
dc.subjectPrimary Ovarian Insufficiency
dc.titleTherapeutic effect of sunitinib on diabetes mellitus related ovarian injury: An experimental rat model study
dc.typeArticle

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