Asymmetric dimethylarginine levels and diabetes duration: Relationship with measures of subclinical atherosclerosis and cardiac function in children and adolescents with Type 1 diabetes

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dc.contributor.authorErsoy, B
dc.contributor.authorEroglu, N
dc.contributor.authorÇetin, M
dc.contributor.authorOnur, E
dc.contributor.authorÖzkol, M
dc.contributor.authorCoskun, S
dc.date.accessioned2024-07-18T11:53:52Z
dc.date.available2024-07-18T11:53:52Z
dc.description.abstractAims: We aimed to evaluate asymmetric dimethylarginine levels in young patients with Type 1 diabetes mellitus according to diabetes duration and to examine the relationship between these levels and measures of atherosclerosis and myocardial function. Materials and methods: In total, 83 patients (8.5-22years) with Type 1 diabetes mellitus were stratified by diabetes duration: 12-60months (Group 1, n=27), >60-120months (Group 2, n=29) and >120months (Group 3, n=27). Asymmetric dimethylarginine levels were assessed. Carotid intima-media thickness was measured. Myocardial function was assessed by M-mode, conventional Doppler and tissue Doppler echocardiography. Results: Asymmetric dimethylarginine level was significantly higher in Group 1, while carotid intima-media thickness was significantly greater in Group 3 (p<0.05). Tissue Doppler echocardiography showed the ratio of peak early to peak late diastolic myocardial annular velocity decreased significantly in Groups 2 and 3 with a negative correlation with duration (r: -0.310, p=0.004) and HBA1c levels (r=-0.391, p<0.001). Myocardial performance index in all groups and isovolumic relaxation time in Group 3 increased significantly. Asymmetric dimethylarginine levels were negatively correlated with carotid intima-media thickness and isovolumic relaxation time (p<0.05). Conclusion: In contrast to adult diabetics, asymmetric dimethylarginine concentration decreases as diabetes duration increases in young Type 1 diabetic patients and is associated with worsening measures of cardiovascular risk and poorer diastolic function.
dc.identifier.issn1479-1641
dc.identifier.other1752-8984
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5945
dc.language.isoEnglish
dc.publisherSAGE PUBLICATIONS LTD
dc.subjectINTIMA-MEDIA THICKNESS
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectYOUNG-PEOPLE
dc.subjectNITRIC-OXIDE
dc.subjectL-ARGININE
dc.subjectHOMOARGININE
dc.subjectHOMOCYSTEINE
dc.subjectASSOCIATION
dc.subjectDYSFUNCTION
dc.subjectMORTALITY
dc.titleAsymmetric dimethylarginine levels and diabetes duration: Relationship with measures of subclinical atherosclerosis and cardiac function in children and adolescents with Type 1 diabetes
dc.typeArticle

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