Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy

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dc.contributor.authorBilgir F.
dc.contributor.authorBilgir O.
dc.contributor.authorCalan M.
dc.contributor.authorCalan O.
dc.contributor.authorIsikyakar T.
dc.date.accessioned2025-04-10T11:13:02Z
dc.date.available2025-04-10T11:13:02Z
dc.date.issued2014
dc.description.abstractObjective: Adhesion molecules are involved in inflammation, atherosclerosis and malignancy. This study measured levels of adhesion molecules before and after levothyroxine therapy in patients with subclinical hypothyroidism (SHO). Methods: Levels of soluble (s) intracellular adhesion molecule (ICAM)-1, s vascular cell adhesion molecule (sVCAM) VCAM-1 and sE-selectin were analysed in patients diagnosed with SHO, prior to administration of 50 mg/day levothyroxine orally for 3 months. Subsequently, levels of sICAM-1, sVCAM-1 and sE-selectin were reanalysed then compared with the pretreatment levels. Results: In 30 patients with SHO, levels of sICAM-1 were found to be significantly higher than those in healthy controls, (P=0.001). Post-treatment sICAM-1 levels were significantly lower than pretreatment levels (P=0.001). No significant differences were found in sVCAM-1 or sE-selectin levels between healthy controls and patients with SHO before treatment, or between patients with SHO pre- and post-treatment. Conclusions: Patients with SHO had significantly higher levels of sICAM-1 compared with controls. Levels became normal after treatment with levothyroxine. These findings emphasize the need for levothyroxine therapy in cases of SHO to normalize sICAM-1 levels. Such treatment helps to prevent the future development of atherosclerosis or cancer. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
dc.identifier.DOI-ID10.1177/0300060514526566
dc.identifier.urihttp://hdl.handle.net/20.500.14701/49740
dc.publisherSAGE Publications Ltd
dc.titleSubclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy
dc.typeArticle

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