G protein β3 subunit gene polymorphism in Turkish hypertensives
| dc.contributor.author | Alioǧlu E. | |
| dc.contributor.author | Ercan E. | |
| dc.contributor.author | Tengiz I. | |
| dc.contributor.author | Yildiz A. | |
| dc.contributor.author | Saygi U.ö.T.S. | |
| dc.contributor.author | Çam F.S. | |
| dc.contributor.author | Berdeli A. | |
| dc.date.accessioned | 2025-04-10T11:16:20Z | |
| dc.date.available | 2025-04-10T11:16:20Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Objective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein β3 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein β3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein β3 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein β3 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (χ2=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein β3 subunit C825T gene polymorphism is associated with systolic a diastolic blood pressure. Furthermore, the study indicates that the G protein β3 subunit may be a susceptible gene to essential hypertension. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51716 | |
| dc.title | G protein β3 subunit gene polymorphism in Turkish hypertensives | |
| dc.type | Article |