Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)
| dc.contributor.author | Moharrami P. | |
| dc.contributor.author | Unak P. | |
| dc.contributor.author | Guldu O.K. | |
| dc.contributor.author | Medine E.I. | |
| dc.contributor.author | Gumuser G. | |
| dc.contributor.author | Bilgin E.S. | |
| dc.contributor.author | Aras O. | |
| dc.date.accessioned | 2025-04-10T11:08:25Z | |
| dc.date.available | 2025-04-10T11:08:25Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies. © 2017, Akadémiai Kiadó, Budapest, Hungary. | |
| dc.identifier.DOI-ID | 10.1007/s10967-017-5630-2 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/48025 | |
| dc.publisher | Springer Netherlands | |
| dc.title | Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP) | |
| dc.type | Article |