Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey

Simple item page
dc.contributor.authorSarikurkcu, C
dc.contributor.authorOzer, MS
dc.contributor.authorIstifli, ES
dc.contributor.authorSahinler, SS
dc.contributor.authorTepe, B
dc.date.accessioned2024-07-18T12:02:52Z
dc.date.available2024-07-18T12:02:52Z
dc.description.abstractSideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in alpha-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and alpha-amylase inhibitory agent. (C) 2021 SAAB. Published by Elsevier B.V. All rights reserved.
dc.identifier.issn0254-6299
dc.identifier.other1727-9321
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8736
dc.language.isoEnglish
dc.publisherELSEVIER
dc.subjectALPHA-AMYLASE
dc.subjectPHENOLIC COMPOSITION
dc.subjectOXIDATIVE STRESS
dc.subjectIN-VITRO
dc.subjectTYROSINASE
dc.subjectGLUCOSIDASE
dc.subjectFLAVONOIDS
dc.subjectMECHANISM
dc.subjectCAPACITY
dc.subjectRADICALS
dc.titleChromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu