Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts

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dc.contributor.authorGok, S
dc.contributor.authorVural, K
dc.contributor.authorSekuri, C
dc.contributor.authorOnur, R
dc.contributor.authorTezcan, A
dc.contributor.authorIzanli, A
dc.date.accessioned2024-07-18T11:54:17Z
dc.date.available2024-07-18T11:54:17Z
dc.description.abstractActivation of ATP-sensitive K+ channels (K-ATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal K-ATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial K-ATP channel blocker on cardiac function and arrhythmias in isolated rat hearts. The hearts were subjected to 30 min coronary occlusion, followed by 30 min reperfusion. In the preischemic period, both HMR 1098 and 5-HD slightly increased coronary perfusion pressure. Coronary occlusion increased the perfusion pressure and decreased the left ventricular developed pressure (LVDP) in both control and drug-treated hearts. However, inhibition of LVDP was greater and recovery of the perfusion pressure was lower in 30 mu mol/l HMR1098 and 100 mu mol/l 5-HD-treated hearts compared to control (P < 0.05). HMR1098, at 3 mu mol/l, but not at 30 mu mol/l, significantly reduced the ratio of bigeminis, couplets and salvos (P < 0.05). Ventricular tachycardia and ventricular fibrillation were not prevented by HMR1098,. at both concentrations, and with 5-HD (100 mu mol/l). These results suggest that blockade of sarcK(ATP) and mitoK(ATP) channels exert weak antiarrhythmic action, but reduce the recovery of coronary perfusion and contractile force, implying that both types of K-ATP channels have beneficial role in the recovery of ischemic rat myocardium. (c) 2005 Elsevier Inc. All rights reserved.
dc.identifier.issn1537-1891
dc.identifier.other1879-3649
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6252
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectMITOCHONDRIAL K-ATP
dc.subjectHMR 1883
dc.subjectVENTRICULAR-FIBRILLATION
dc.subjectMYOCARDIAL-ISCHEMIA
dc.subjectCARDIOSELECTIVE INHIBITOR
dc.subjectFUNCTIONAL ROLES
dc.subjectCARDIOPROTECTION
dc.subjectGLIBENCLAMIDE
dc.subjectINFARCTION
dc.subjectMORTALITY
dc.titleEffects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts
dc.typeArticle

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