Evaluation of Castration-Resistant Elderly Patients
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Date
2021
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Abstract
Objectives: In the present time suggesting an extended human lifespan and expectancy, elderly patients receive asignificant portion of daily healthcare practice whereas they have not been sufficiently addressed in the extensiveand comprehensive clinical studies. We have desgined our study to evaluate the treatment options in this metastaticcastration-resistant prostate cancer patients older than 70 years. Methods: Our study is retrospective. The data of the patients from 5 centers of Turkey were obtained. The patients aged70 years and over were assigned to a group (geriatric group) while the rest of the patients were evaluated in anothergroup (normal group). The primary endpoint of the study was determined as overall survival time. Results: Totally 113 patients were included in our study. The geriatric and normal groups included 58 and 55 patients,respectively. Overall survival as the primary endpoint of our study demonstrated no statistically significant differencebetween survival of the patients aged over 70 years and other patients (geriatric group versus normal group, respectively 18.86 versus 23.93 months, respectively, p=0,542). Progresion-free survival as the secondary endpoint; no statistically significant difference was detected between two groups (geriatric group vs normal group, median 7.83 vs 8.5months, respectively, p=0.73). Conclusion: It was detected that the age variable has a negative impact on overall survival of prostate cancer cases.The overall survival was found numerically shorter in the patients aged 70 years and over set as age limit, however, thisdifference was not found statistically significant.