Serum hypoxia-inducible factor-2: A candidate prognostic biomarker for laryngeal cancer

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dc.contributor.authorEskiizmir, G
dc.contributor.authorKoçal, GÇ
dc.contributor.authorUysal, T
dc.contributor.authorEllidokuz, H
dc.contributor.authorBaspinar, Y
dc.date.accessioned2024-07-18T11:53:30Z
dc.date.available2024-07-18T11:53:30Z
dc.description.abstractObjectives To determine the serum hypoxia-inducible factor-1, -2 and -3 (HIF-1, -2 and -3) levels in patients with laryngeal neoplasm, and to investigate their role in differential diagnosis, prediction of tumour characteristic and extension, and prognosis and survival. Study Design Prospective, cohort study at a tertiary referral centre. Settings The study was conducted in a tertiary medical centre. Participants Patients with benign, premalignant and malignant laryngeal neoplasms were included. Sixty-four patients with a laryngeal neoplasm were enrolled. Main Outcome Measures Serum HIF-1, -2 and -3 levels were measured from blood samples that were drawn before treatment, using ELISA. Results A statistically significant difference between benign (HIF-1, -2, -3:4046,1 pg/mL; 2581,5 pg/mL; 1321,0 pg/mL), premalignant (HIF-1, -2, -3:3630,3 pg/mL; 3229,7 pg/mL; 2549,8 pg/mL) and malignant (HIF-1, -2, -3:3576,7 pg/mL; 2595,8 pg/mL; 1106,3 pg/mL) laryngeal neoplasms was not detected when serum HIF-1, -2 and -3 levels were compared. However, high serum HIF-2 level adversely affected survival and locoregional control and had more than 7-fold increase in hazard ratio. Moreover, serum HIF-2 was an independent prognostic factor for 2-year overall, disease-free, distant metastasis-free survival and locoregional control. Conclusion This is the first clinical study in which the diagnostic, predictive and prognostic roles of hypoxia-related biomolecules were examined in laryngeal neoplasms. Hypoxia-inducible factor-2 is a prognostic factor in larynx cancer irrespective of treatment modality.
dc.identifier.issn1749-4478
dc.identifier.other1749-4486
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5663
dc.language.isoEnglish
dc.publisherWILEY
dc.subjectSQUAMOUS-CELL CARCINOMA
dc.subjectTUMOR MICROENVIRONMENT
dc.subjectCA-IX
dc.subjectCLINICAL-RELEVANCE
dc.subjectPREDICTIVE-VALUE
dc.subjectGROWTH-FACTOR
dc.subjectRISK-FACTORS
dc.subjectHEAD
dc.subjectHIF-2-ALPHA
dc.subjectANEMIA
dc.titleSerum hypoxia-inducible factor-2: A candidate prognostic biomarker for laryngeal cancer
dc.typeArticle

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