Comparison of nephron-protective effects of enalapril and glp analogues (exenatide) in diabetic nephropathy

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dc.contributor.authorÇavusoglu T.
dc.contributor.authorErbas O.
dc.contributor.authorKaradeniz T.
dc.contributor.authorAkdemir O.
dc.contributor.authorAcikgoz E.
dc.contributor.authorKaradeniz M.
dc.contributor.authorTuglu M.I.
dc.contributor.authorAtes U.
dc.date.accessioned2024-07-22T08:17:17Z
dc.date.available2024-07-22T08:17:17Z
dc.date.issued2014
dc.description.abstractBackground: One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. Aim: To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin. Material and Methods: 32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM+ Enalapril, and (4) DM+ exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria. Results: Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically. Conclusion: The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy. © 2014 Georg Thieme Verlag KG Stuttgart New York.
dc.identifier.DOI-ID10.1055/s-0034-1372584
dc.identifier.issn09477349
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17018
dc.language.isoEnglish
dc.publisherGeorg Thieme Verlag
dc.subjectAnimals
dc.subjectAntihypertensive Agents
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Nephropathies
dc.subjectEnalapril
dc.subjectGene Expression Regulation, Enzymologic
dc.subjectHypoglycemic Agents
dc.subjectMale
dc.subjectNephrons
dc.subjectNitric Oxide Synthase Type II
dc.subjectPeptides
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectVenoms
dc.subjectcreatinine
dc.subjectenalapril
dc.subjectexendin 4
dc.subjectfibronectin
dc.subjectglucagon like peptide 1
dc.subjectglucose
dc.subjectinducible nitric oxide synthase
dc.subjectservier
dc.subjectunclassified drug
dc.subjectantidiabetic agent
dc.subjectantihypertensive agent
dc.subjectenalapril
dc.subjectexendin 4
dc.subjectinducible nitric oxide synthase
dc.subjectNos2 protein, rat
dc.subjectpeptide
dc.subjectvenom
dc.subjectanalytical equipment
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectautoanalyzer
dc.subjectbrush border
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectdiabetic nephropathy
dc.subjectdilatation
dc.subjectdissociation
dc.subjectdrug effect
dc.subjectglomerular structure
dc.subjectglomerulus
dc.subjectglucose blood level
dc.subjecthistopathology
dc.subjectimmunity
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectinvestigative procedures
dc.subjectkidney parenchyma
dc.subjectkidney tubule epithelium
dc.subjectmale
dc.subjectnephrectomy
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein depletion
dc.subjectprotein determination
dc.subjectprotein expression
dc.subjectprotein urine level
dc.subjectproteinuria
dc.subjectrat
dc.subjectrenal protection
dc.subjecttreatment response
dc.subjecttubular dilatation
dc.subjecturea nitrogen blood level
dc.subjecturinalysis
dc.subjecturine dipstick
dc.subjectanimal
dc.subjectbiosynthesis
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Nephropathies
dc.subjectdrug effects
dc.subjectgene expression regulation
dc.subjectmetabolism
dc.subjectnephron
dc.subjectpathology
dc.subjectSprague Dawley rat
dc.titleComparison of nephron-protective effects of enalapril and glp analogues (exenatide) in diabetic nephropathy
dc.typeArticle

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