Single voxel in vivo proton magnetic resonance spectroscopy of breast lesions: experience in 77 cases

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dc.contributor.authorBasara, I
dc.contributor.authorÖrgüç, S
dc.contributor.authorCoskun, T
dc.date.accessioned2024-07-18T11:48:46Z
dc.date.available2024-07-18T11:48:46Z
dc.description.abstractPURPOSE We aimed to determine the value of in vivo single voxel proton magnetic resonance spectroscopy (MRS) in characterizing breast lesions. MATERIALS AND METHODS Breast MRS was performed in 77 patients. Choline resonance peak at 3.2 parts per million (ppm) was defined positive when it was at least two times higher than baseline. MRS findings were compared with the final diagnosis of cases for two different values (3.23 and 3.28 ppm). RESULTS Thirty-one malignant and 13 benign lesions had choline peaks. Sensitivity was 84%, specificity was 64%. Positive likelihood ratio (LHR) was 2.32, negative LHR was 0.25. Twenty-two malignant and 5 benign lesions had a peak at 3.23 ppm. Nine malignant and 8 benign lesions had a peak at 3.28 ppm. When 3.23 ppm was accepted as positive; sensitivity, specificity, and positive and negative LHRs were 79%, 82%, 4.4, and 0.26, respectively. CONCLUSION MRS provides additional parameters on evaluation of breast lesions. However, MRS of breast has some false negative results, thus it is still insufficient in clinical diagnosis.
dc.identifier.issn1305-3825
dc.identifier.other1305-3612
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3497
dc.language.isoEnglish
dc.publisherAVES
dc.subjectCHOLINE PHOSPHOLIPID-METABOLISM
dc.subjectMR SPECTROSCOPY
dc.subjectCANCER
dc.subjectBENIGN
dc.subjectDIAGNOSIS
dc.subjectMALIGNANCY
dc.subjectMARKERS
dc.titleSingle voxel in vivo proton magnetic resonance spectroscopy of breast lesions: experience in 77 cases
dc.typeArticle

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