The Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage; [Gentamisin ile Oluşturulan Kohlear Hasar üzerine N-Asetilsisteinin Nörofilament ve Sinir Büyüme Faktörü Salınımına Etkisi]
| dc.contributor.author | Sarsmaz H.Y. | |
| dc.contributor.author | Gürgen S.G. | |
| dc.contributor.author | Somdaş M.A. | |
| dc.date.accessioned | 2025-04-10T11:04:59Z | |
| dc.date.available | 2025-04-10T11:04:59Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Objective: To investigate of the effectiveness of N-acetylcysteine (NAC) in preventing cochlear damage due to gentamicin by the means of expression of neuronal factors Metods: In our study, 36 female Spraguea Dawley rats were used. They were divided into 3 groups such as (saline), Gentamicin + Serum physiological (saline) and Gentamicin + NAC. After 15 days, the rats were sacrificed. Cochleae were removed and examined histopathologically. The immunoreactivity of neurofilament and neuronal growth factor primary antibodies was examined in the tissues taken. Results: Neuroflament immunoreactivity was quite significant in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, whereas it was weak in the Gentamicin + serum physiological group. Also neuronal growth factor immunoreactivity was moderate in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, it was negative at vestibular ganglia, and weak in afferent and efferent nerve fiber bundles in the Gentamicin + serum physiological group. Conclusion: It was shown immunohistochemically that ototoxicity caused by gentamicin was significantly reduced when the NAC combination was applied. © Copyright 2022 by Gazi University Medical Faculty | |
| dc.identifier.DOI-ID | 10.12996/gmj.2022.54 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/45764 | |
| dc.publisher | Gazi Universitesi | |
| dc.title | The Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage; [Gentamisin ile Oluşturulan Kohlear Hasar üzerine N-Asetilsisteinin Nörofilament ve Sinir Büyüme Faktörü Salınımına Etkisi] | |
| dc.type | Article |