Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients?
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Date
2012
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Abstract
To determine the risk of an association with some genetic polymorphisms involved in venous thromboembolism (VTE) gene variations (FVL, FV H1299R, FII G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G,β-fibrinogen -455 G ] A, FXIII Val34Leu and GpIIIa HPA-1a) in cancer patients. Subjects and Methods: Among 78 cancer patients, 28 who had proven first episode of VTE were selected as the patient group, with 50 control samples selected from age-, sex- and body mass index-matched healthy volunteers (healthy group). The differences in frequency of genetic polymorphisms were found to be statistically insignificant between these two groups. Results: Logistic regression analysis after adjustment for age, sex, smoking and hypertension showed no difference. The screened mutations of these genes were not significantly associated with VTE risk. Conclusion: There is no possible benefit from genetic screening tests regarding VTE in cancer patients. © 2011 S. Karger AG, Basel.
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Keywords
Disease Susceptibility , Female , Genetic Testing , Humans , Male , Middle Aged , Neoplasms , Polymorphism, Genetic , Venous Thromboembolism , adult , article , cancer patient , clinical article , controlled study , disease association , female , gene frequency , genetic polymorphism , genetic screening , genotype , human , male , risk , venous thromboembolism