Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients?

Simple item page
dc.contributor.authorOnur E.
dc.contributor.authorKurdal A.T.
dc.contributor.authorTugrul B.
dc.contributor.authorIskesen I.
dc.contributor.authorDundar P.
dc.contributor.authorTaneli F.
dc.contributor.authorUlman C.
dc.contributor.authorVar A.
dc.date.accessioned2024-07-22T08:19:29Z
dc.date.available2024-07-22T08:19:29Z
dc.date.issued2012
dc.description.abstractTo determine the risk of an association with some genetic polymorphisms involved in venous thromboembolism (VTE) gene variations (FVL, FV H1299R, FII G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G,β-fibrinogen -455 G ] A, FXIII Val34Leu and GpIIIa HPA-1a) in cancer patients. Subjects and Methods: Among 78 cancer patients, 28 who had proven first episode of VTE were selected as the patient group, with 50 control samples selected from age-, sex- and body mass index-matched healthy volunteers (healthy group). The differences in frequency of genetic polymorphisms were found to be statistically insignificant between these two groups. Results: Logistic regression analysis after adjustment for age, sex, smoking and hypertension showed no difference. The screened mutations of these genes were not significantly associated with VTE risk. Conclusion: There is no possible benefit from genetic screening tests regarding VTE in cancer patients. © 2011 S. Karger AG, Basel.
dc.identifier.DOI-ID10.1159/000333394
dc.identifier.issn14230151
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17685
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectDisease Susceptibility
dc.subjectFemale
dc.subjectGenetic Testing
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasms
dc.subjectPolymorphism, Genetic
dc.subjectVenous Thromboembolism
dc.subjectadult
dc.subjectarticle
dc.subjectcancer patient
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic polymorphism
dc.subjectgenetic screening
dc.subjectgenotype
dc.subjecthuman
dc.subjectmale
dc.subjectrisk
dc.subjectvenous thromboembolism
dc.titleIs genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients?
dc.typeArticle

Files

Collections

Scopus Koleksiyonu