Effects of verteporfin-mediated photodynamic therapy in breast cancer cells

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dc.contributor.authorSönmez, PK
dc.contributor.authorTurhan, A
dc.contributor.authorÖztatlici, M
dc.contributor.authorÖzbilgin, K
dc.date.accessioned2024-07-18T11:49:10Z
dc.date.available2024-07-18T11:49:10Z
dc.description.abstractPhotodynamic therapy works with a photosensitizer that is stimulated when exposed to a light source of a specific wavelength and produces a form of oxygen that can be used in cancer treatments. In this study, we investigated the effect of laser on apoptosis on breast cancer cell lines (MDA-MB-231) treated with verteporfin in cell culture media. Verteporfin added MDA-MB-231 cells were incubated without light for 24 hours after applying laser light at a wavelength of 695 nm at an intensity of 50 J/cm2 at various times. Anti-proliferative effects were evaluated by immunoreactivity of anti-Bcl-2 and anti-Bax antibodies by immunocytochemical staining. When anti-Bax/Anti-Bcl-2 ratio are compared, the ratio of 1.5 in the control group cells decreases in short-term laser applications, while it approaches normal values in the 7th min after longterm laser application and reaches a very high value in the 9th min. Therefore, our results suggest that verteporfin-mediated PDT may be a potential combined therapy strategy against breast carcinoma by increasing apoptosis.
dc.identifier.issn0301-1208
dc.identifier.other0975-0959
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3812
dc.language.isoEnglish
dc.publisherNATL INST SCIENCE COMMUNICATION-NISCAIR
dc.subjectDNA-DAMAGE
dc.subjectIN-VIVO
dc.subjectAPOPTOSIS
dc.subjectPHOTOCHEMISTRY
dc.subjectGROWTH
dc.subjectPROLIFERATION
dc.subjectMITOCHONDRIAL
dc.subjectINHIBITION
dc.subjectEXPRESSION
dc.subjectBCL-2
dc.titleEffects of verteporfin-mediated photodynamic therapy in breast cancer cells
dc.typeArticle

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