Significance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-α
| dc.contributor.author | Zeren T. | |
| dc.contributor.author | Inan S. | |
| dc.contributor.author | Seda Vatansever H. | |
| dc.contributor.author | Ekerbicer N. | |
| dc.contributor.author | Sayhan S. | |
| dc.date.accessioned | 2025-04-10T11:16:29Z | |
| dc.date.available | 2025-04-10T11:16:29Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α) are members of the polypeptide growth factor family. The epidermal growth factor-receptor (EGF-R) is a receptor tyrosine kinase of the ErbB family. Many types of cancer, including ovarian cancer, display enhanced EGF-R immunoreactivity on their cell surface membranes. Also, an increase in TGF-α synthesis and secretion usually occurs in human carcinoma cell lines. In this study, we compared the immunoreactivities of TGF-α and EGF-R in ovarian tumors and related immunohistochemical findings to the histological type of the tumors. Formalin-fixed, paraffin wax-embedded tissue sections from 40 patients who had serous-mucinous borderline tumor and serous-mucinous adenocarcinoma of the ovary (n=10 each) were stained with hematoxylin-eosin and labeled for binding of primary antibodies against TGF-α and EGF-R using an avidin-biotin-peroxidase method. A semi-quantitative grading system was used to compare immunohistochemical labeling intensities. Increased immunoreactivity of EGF-R and moderate immunoreactivity of TGF-α was detected in adenocarcinomas. There was no significant difference in the immunoreactivity of TGF-α among the histologic types of ovarian tumors. The results of this study support the hypothesis that EGF-R may be a more useful marker than TGF-α in epithelial ovarian tumors. © 2007 Elsevier GmbH. All rights reserved. | |
| dc.identifier.DOI-ID | 10.1016/j.acthis.2007.08.007 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51844 | |
| dc.publisher | Elsevier GmbH | |
| dc.title | Significance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-α | |
| dc.type | Article |