Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)

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dc.contributor.authorMoharrami, P
dc.contributor.authorUnak, P
dc.contributor.authorGuldu, OK
dc.contributor.authorMedine, EI
dc.contributor.authorGumuser, G
dc.contributor.authorBilgin, ES
dc.contributor.authorAras, O
dc.date.accessioned2024-07-18T12:00:58Z
dc.date.available2024-07-18T12:00:58Z
dc.description.abstractA theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with Tc-99m which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of Tc-99m-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that Tc-99m-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.
dc.identifier.issn0236-5731
dc.identifier.other1588-2780
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8084
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectPROSTATE-CANCER CELLS
dc.subjectBREAST-CANCER
dc.subjectIN-VITRO
dc.subjectER-ALPHA
dc.subjectTISSUE DISTRIBUTION
dc.subjectBETA
dc.subjectBIODISTRIBUTION
dc.subjectEXPRESSION
dc.subjectRATS
dc.subjectFIBROBLASTS
dc.titleMultifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)
dc.typeArticle

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