A whole genome screen for linkage in Turkish multiple sclerosis
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Date
2003
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Abstract
Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. © 2003 Elsevier B.V. All rights reserved.
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adult , biological trait , chromosome 13q , chromosome 18p , chromosome 18q , chromosome 19p , chromosome 5p , chromosome 8p , conference paper , consanguineous marriage , controlled study , cultural factor , female , gene linkage disequilibrium , genetic linkage , genetic screening , human , major clinical study , male , microsatellite marker , multiple sclerosis , priority journal , Turkey (republic)