A whole genome screen for linkage in Turkish multiple sclerosis

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dc.contributor.authorEraksoy M.
dc.contributor.authorKurtuncu M.
dc.contributor.authorAkman-Demir G.
dc.contributor.authorKilinc M.
dc.contributor.authorGedizlioglu M.
dc.contributor.authorMirza M.
dc.contributor.authorAnlar Ö.
dc.contributor.authorKutlu C.
dc.contributor.authorDemirkiran M.
dc.contributor.authorIdrisoglu H.A.
dc.contributor.authorCompston A.
dc.contributor.authorSawcer S.
dc.contributor.authorTombul T.
dc.contributor.authorAsker Ö.
dc.contributor.authorBalkan S.
dc.contributor.authorSeçkin D.
dc.contributor.authorAydin H.
dc.contributor.authorAkman-Demir G.
dc.contributor.authorKiyat A.
dc.contributor.authorYapici Z.
dc.contributor.authorEpçeliden T.
dc.contributor.authorÇe P.
dc.contributor.authorGoldenberg E.
dc.contributor.authorGültiken B.
dc.contributor.authorGüvenç A.
dc.contributor.authorIşik N.
dc.contributor.authorSeleker T.
dc.contributor.authorIdiman E.
dc.contributor.authorÖzakbaş S.
dc.contributor.authorIrkeç C.
dc.contributor.authorNazlier B.
dc.contributor.authorForta H.
dc.contributor.authorSeleker F.
dc.contributor.authorGüner K.
dc.contributor.authorKarabudak R.
dc.contributor.authorKilinç M.
dc.contributor.authorKomsuoǧlu S.
dc.contributor.authorEfendi H.
dc.contributor.authorMert M.
dc.contributor.authorMirza M.
dc.contributor.authorErdoǧan F.
dc.contributor.authorMüngen B.
dc.contributor.authorBulut S.
dc.contributor.authorÖzer F.
dc.contributor.authorYayla V.
dc.contributor.authorPetek-Balci B.
dc.contributor.authorSaǧduyu A.
dc.contributor.authorSarica Y.
dc.contributor.authorDemirkiran M.
dc.contributor.authorSelçuki D.
dc.contributor.authorMavioǧlu H.
dc.contributor.authorSiva A.
dc.contributor.authorAltintaş A.
dc.contributor.authorSaip S.
dc.contributor.authorSütlaş N.
dc.contributor.authorKuşçu Yandim D.
dc.contributor.authorTireli H.
dc.contributor.authorÖzalp K.
dc.contributor.authorTürkoǧlu R.
dc.contributor.authorÖrken C.
dc.contributor.authorÖzmanoǧlu M.
dc.contributor.authorVelioǧlu S.
dc.contributor.authorÖzdemir G.
dc.contributor.authorGücüyener D.
dc.contributor.authorÖzkan S.
dc.contributor.authorTunali G.
dc.contributor.authorTuran F.
dc.contributor.authorUtku U.
dc.contributor.authorTurgut N.
dc.contributor.authorÜmit S.
dc.contributor.authorUs Ö.
dc.contributor.authorInce Günal D.
dc.contributor.authorÜtkür Y.
dc.contributor.authorAluçlu U.
dc.contributor.authorYavaşoǧlu Ö.
dc.contributor.authorYücemen N.
dc.contributor.authorYücesan C.
dc.contributor.authorZadikoǧlu A.
dc.contributor.authorZorlu Y.
dc.date.accessioned2024-07-22T08:24:47Z
dc.date.available2024-07-22T08:24:47Z
dc.date.issued2003
dc.description.abstractFactors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity, increased the LOD scores in four regions. © 2003 Elsevier B.V. All rights reserved.
dc.identifier.DOI-ID10.1016/j.jneuroim.2003.08.006
dc.identifier.issn01655728
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20130
dc.language.isoEnglish
dc.publisherElsevier
dc.subjectadult
dc.subjectbiological trait
dc.subjectchromosome 13q
dc.subjectchromosome 18p
dc.subjectchromosome 18q
dc.subjectchromosome 19p
dc.subjectchromosome 5p
dc.subjectchromosome 8p
dc.subjectconference paper
dc.subjectconsanguineous marriage
dc.subjectcontrolled study
dc.subjectcultural factor
dc.subjectfemale
dc.subjectgene linkage disequilibrium
dc.subjectgenetic linkage
dc.subjectgenetic screening
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicrosatellite marker
dc.subjectmultiple sclerosis
dc.subjectpriority journal
dc.subjectTurkey (republic)
dc.titleA whole genome screen for linkage in Turkish multiple sclerosis
dc.typeConference paper

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