Comparison of immunogenicity for Sinovac-CoronaVac vaccine vs. natural infection during cancer treatment

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dc.contributor.authorÇakir E.
dc.contributor.authorSaydan D.
dc.contributor.authorGülbagci B.
dc.contributor.authorÖzen M.
dc.contributor.authorUǧurlu İ.
dc.contributor.authorDemirci A.
dc.contributor.authorBilir F.
dc.contributor.authorHacibekiroglu İ.
dc.contributor.authorYildiz N.
dc.contributor.authorAkcali S.
dc.contributor.authorAltindis M.
dc.contributor.authorVarim C.
dc.contributor.authorYaylaci S.
dc.contributor.authorBilir C.
dc.date.accessioned2025-04-10T11:03:55Z
dc.date.available2025-04-10T11:03:55Z
dc.date.issued2023
dc.description.abstractOBJECTIVE: Efficacy of the COVID-19 vaccines in cancer patients, especially during their active treatment, are lacking. Most of the studies in the literature compared the immunity in cancer patients with a cross-sectional cohort or retrospectively. Our study investigated Sinovac- CoronaVac COVID-19 vaccine immunogenicity and compared it with natural COVID-19 disease in cancer patients during their cancer therapy. PATIENTS AND METHODS: A total of 111 patients with cancer and who are on active treatment were included in the study. This is a single- center study and was designed prospectively. Two group of patients were included in the study, natural disease and vaccinated group. RESULTS: A total of 111 patients were included in the study, 34 of whom had natural COVID-19 disease. Antibody levels following the first dose vaccine were 0.4 (0-1.9) U/ml while after the second dose of vaccine were 2.6 (1.0- 7.25) U/ml. Immunogenicity levels were 82.4% in the natural disease group and 75.8% in the vaccinated group after the second shot of the vaccine. Immunogenicity rate was significantly higher in non-chemotherapy (receiving immunotehrapy/ targeted therapy or biologic agent) group compared to chemotherapy drug (92.9% vs. 63.3%, p=0.004). There was a difference between the antibody levels following the first and second vaccination [median (IQR): 0.3 (0-1.0) and 3.3 (2.0-6.7), p=0.001, respectively]. CONCLUSIONS: The present study revealed that the Sinovac-CoronaVac vaccine showed an acceptable immunogenicity following two shots in cancer patients who were receiving active systemic therapy. On the other hand, natural disease immunogenicity was higher than vaccinated group. © 2023 Verduci Editore s.r.l. All rights reserved.
dc.identifier.DOI-ID10.26355/eurrev_202305_32341
dc.identifier.urihttp://hdl.handle.net/20.500.14701/45020
dc.publisherVerduci Editore s.r.l
dc.titleComparison of immunogenicity for Sinovac-CoronaVac vaccine vs. natural infection during cancer treatment
dc.typeArticle

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