Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

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dc.contributor.authorKaba, M
dc.contributor.authorPirincci, N
dc.contributor.authorBenli, E
dc.contributor.authorGecit, I
dc.contributor.authorGunes, M
dc.contributor.authorYuksel, MB
dc.contributor.authorTok, A
dc.contributor.authorKemik, AS
dc.date.accessioned2024-07-18T12:06:16Z
dc.date.available2024-07-18T12:06:16Z
dc.description.abstractBackground: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
dc.identifier.issn1513-7368
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10274
dc.language.isoEnglish
dc.publisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
dc.subjectCLINICAL-SIGNIFICANCE
dc.subjectSERUM
dc.subjectFAMILY
dc.subjectDKK-1
dc.titleDickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features
dc.typeArticle

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