Evaluation of heterozygous deletion of TP53 gene in pleural fluid samples: A case series of 11 patients; [Plevral Sıvı Örneklerinde TP53 Geni Heterozigot Delesyonunun Değerlendirilmesi: 11 Hastalık Bir Seri]
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Date
2016
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Abstract
We described heterozygous deletion of tumor protein 53 (TP53) gene in 11 patients including 2 patients with non-malignant diseases (pneumonia) and 9 patients with malignant diseases [including small cell lung cancer (n = 3), non-small cell lung carcinoma (n = 4), non-Hodgkin’s lymphoma (n=1), and gastric carcinoma (n=1)]. Chromosomal aberrant status was analyzed by fluorescence in situ hybridization with centromere specific and 17p13.1 locus specific probes. In 3 of 9 cancer patients we did not find malignant pleural effusion with histological examination and/or closed pleural biopsy. Heterozygous deletion of TP53 gene was found to be significantly higher in patients with malignant disease when compared to the patients with benign pleural fluid. As a result, we suggest that heterozygous deletion of TP53 may have indicator value for malignancy; however further studies are warranted to confirm this suggestion in large patient cohorts. © 2016, Journal of Clinical and Analytical Medicine. All Rights Reserved.
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adult , advanced cancer , aged , Article , cancer staging , case study , centromere , chromosome 17p , clinical article , cohort analysis , controlled study , female , fluorescence in situ hybridization , gene deletion , gene locus , genetic association , heterozygote , human , human tissue , male , malignant pleura effusion , middle aged , non small cell lung cancer , nonhodgkin lymphoma , pleura biopsy , pleura fluid , pneumonia , small cell lung cancer , stomach carcinoma , tumor suppressor gene , very elderly