Evaluation of heterozygous deletion of TP53 gene in pleural fluid samples: A case series of 11 patients; [Plevral Sıvı Örneklerinde TP53 Geni Heterozigot Delesyonunun Değerlendirilmesi: 11 Hastalık Bir Seri]

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dc.contributor.authorDirican N.
dc.contributor.authorBagci Ö.
dc.contributor.authorUz E.
dc.contributor.authorÖztürk Ö.
dc.contributor.authorBircan H.
dc.contributor.authorDirican A.
dc.date.accessioned2024-07-22T08:12:20Z
dc.date.available2024-07-22T08:12:20Z
dc.date.issued2016
dc.description.abstractWe described heterozygous deletion of tumor protein 53 (TP53) gene in 11 patients including 2 patients with non-malignant diseases (pneumonia) and 9 patients with malignant diseases [including small cell lung cancer (n = 3), non-small cell lung carcinoma (n = 4), non-Hodgkin’s lymphoma (n=1), and gastric carcinoma (n=1)]. Chromosomal aberrant status was analyzed by fluorescence in situ hybridization with centromere specific and 17p13.1 locus specific probes. In 3 of 9 cancer patients we did not find malignant pleural effusion with histological examination and/or closed pleural biopsy. Heterozygous deletion of TP53 gene was found to be significantly higher in patients with malignant disease when compared to the patients with benign pleural fluid. As a result, we suggest that heterozygous deletion of TP53 may have indicator value for malignancy; however further studies are warranted to confirm this suggestion in large patient cohorts. © 2016, Journal of Clinical and Analytical Medicine. All Rights Reserved.
dc.identifier.DOI-ID10.4328/JCAM.4551
dc.identifier.issn13090720
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16016
dc.language.isoEnglish
dc.publisherDerman Medical Publishing
dc.rightsAll Open Access; Bronze Open Access
dc.subjectadult
dc.subjectadvanced cancer
dc.subjectaged
dc.subjectArticle
dc.subjectcancer staging
dc.subjectcase study
dc.subjectcentromere
dc.subjectchromosome 17p
dc.subjectclinical article
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfluorescence in situ hybridization
dc.subjectgene deletion
dc.subjectgene locus
dc.subjectgenetic association
dc.subjectheterozygote
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmale
dc.subjectmalignant pleura effusion
dc.subjectmiddle aged
dc.subjectnon small cell lung cancer
dc.subjectnonhodgkin lymphoma
dc.subjectpleura biopsy
dc.subjectpleura fluid
dc.subjectpneumonia
dc.subjectsmall cell lung cancer
dc.subjectstomach carcinoma
dc.subjecttumor suppressor gene
dc.subjectvery elderly
dc.titleEvaluation of heterozygous deletion of TP53 gene in pleural fluid samples: A case series of 11 patients; [Plevral Sıvı Örneklerinde TP53 Geni Heterozigot Delesyonunun Değerlendirilmesi: 11 Hastalık Bir Seri]
dc.typeArticle

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