The association of apolipoprotein E polymorphism and Lipid levels in children with a family history of premature coronary artery disease

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dc.contributor.authorÇiftdogan, DY
dc.contributor.authorCoskun, S
dc.contributor.authorUlman, C
dc.contributor.authorTikiz, H
dc.date.accessioned2024-07-18T11:49:09Z
dc.date.available2024-07-18T11:49:09Z
dc.description.abstractBACKGROUND: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, they have been associated with relative risk of coronary artery disease (CAD). OBJECTIVE: To evaluate the association of apolipoprotein E polymorphism and lipid levels in children with family history of premature coronary artery disease. METHODS: The apoE genotypes, allele frequencie,s and plasma lipid levels were analyzed in 137 children. Among these children, 70 (study group) had and 67 (control group) did not have a parental history of premature CAD RESULTS: Total cholesterol (TO levels were greater in the study group (P = .04). The frequencies of epsilon 3 epsilon 4 genotype and epsilon 4 allele were significantly greater in the study group (P = 005 for both), The epsilon 2 allele correlated negatively with Tc and low-density lipoprotein cholesterol levels, and e4 had a positive correlation with Tc and low-density lipoprotein cholesterol levels. CONCLUSIONS: Tc levels are influenced by apoE genotypes in childhood. Also, the frequency of the epsilon 4 allele is greater in children with family history of premature CAD. The e4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of Tc in children with family history of CAD. The evaluation of apoE gene polymorhisms may contribute to the assessment of cardiovascular risk in children with a family history of CAD. (C) 2012 National Lipid Association. All rights reserved.
dc.identifier.issn1933-2874
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3793
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectCARDIOVASCULAR RISK-FACTORS
dc.subjectDENSITY LIPOPROTEIN CHOLESTEROL
dc.subjectHEART-DISEASE
dc.subjectE GENOTYPES
dc.subjectE PHENOTYPE
dc.subjectUNITED-STATES
dc.subjectSERUM-LIPIDS
dc.subjectATHEROSCLEROSIS
dc.subjectPLASMA
dc.subjectGENDER
dc.titleThe association of apolipoprotein E polymorphism and Lipid levels in children with a family history of premature coronary artery disease
dc.typeArticle

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