The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice
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Date
2000
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Abstract
The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. Copyright (C) 2000 Elsevier Science B.V.
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Keywords
4-Aminopyridine , Amnesia , Animal , Apamin , Avoidance Learning , Electroshock , Male , Mice , Muscarinic Antagonists , Potassium Channel Blockers , Retention (Psychology) , Scopolamine , Support, Non-U.S. Gov't , 3,4 diaminopyridine , 4 aminopyridine , apamin , potassium channel blocking agent , scopolamine , amnesia , animal experiment , animal model , article , controlled study , electric shock , male , mouse , nonhuman , passive avoidance , priority journal