The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

Simple item page
dc.contributor.authorInan S.Y.
dc.contributor.authorAksu F.
dc.contributor.authorBaysal F.
dc.date.accessioned2024-07-22T08:25:35Z
dc.date.available2024-07-22T08:25:35Z
dc.date.issued2000
dc.description.abstractThe effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. Copyright (C) 2000 Elsevier Science B.V.
dc.identifier.DOI-ID10.1016/S0014-2999(00)00736-6
dc.identifier.issn00142999
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20473
dc.language.isoEnglish
dc.subject4-Aminopyridine
dc.subjectAmnesia
dc.subjectAnimal
dc.subjectApamin
dc.subjectAvoidance Learning
dc.subjectElectroshock
dc.subjectMale
dc.subjectMice
dc.subjectMuscarinic Antagonists
dc.subjectPotassium Channel Blockers
dc.subjectRetention (Psychology)
dc.subjectScopolamine
dc.subjectSupport, Non-U.S. Gov't
dc.subject3,4 diaminopyridine
dc.subject4 aminopyridine
dc.subjectapamin
dc.subjectpotassium channel blocking agent
dc.subjectscopolamine
dc.subjectamnesia
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectelectric shock
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpassive avoidance
dc.subjectpriority journal
dc.titleThe effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice
dc.typeArticle

Files

Collections

Scopus Koleksiyonu