Prevention of posterior capsule opacification by retinoic acid and mitomycin
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Date
2001
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Abstract
Background: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 μg/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P<0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multi-layer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation.
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Keywords
Animals , Antimetabolites , Cataract , Cell Division , Epithelial Cells , Intraoperative Period , Lens Capsule, Crystalline , Mitomycin , Ophthalmic Solutions , Phacoemulsification , Rabbits , Random Allocation , Tretinoin , acri vics , fenilefrin , ketamine , methylcellulose , mitomycin , oxybuprocaine , phenylephrine , retinoic acid , siklomid , thiopental , tropicamide , animal experiment , animal model , animal tissue , article , cataract , cell proliferation , controlled study , cornea edema , dose response , drug efficacy , epithelium cell , intraoperative period , lens epithelium , nonhuman , phacoemulsification , priority journal , rabbit , randomization