Prevention of posterior capsule opacification by retinoic acid and mitomycin

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dc.contributor.authorInan U.U.
dc.contributor.authorÖztürk F.
dc.contributor.authorKaynak S.
dc.contributor.authorIlker S.S.
dc.contributor.authorÖzer E.
dc.contributor.authorGüler C.
dc.date.accessioned2024-07-22T08:25:30Z
dc.date.available2024-07-22T08:25:30Z
dc.date.issued2001
dc.description.abstractBackground: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 μg/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P<0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multi-layer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation.
dc.identifier.DOI-ID10.1007/s004170100329
dc.identifier.issn0721832X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20461
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAntimetabolites
dc.subjectCataract
dc.subjectCell Division
dc.subjectEpithelial Cells
dc.subjectIntraoperative Period
dc.subjectLens Capsule, Crystalline
dc.subjectMitomycin
dc.subjectOphthalmic Solutions
dc.subjectPhacoemulsification
dc.subjectRabbits
dc.subjectRandom Allocation
dc.subjectTretinoin
dc.subjectacri vics
dc.subjectfenilefrin
dc.subjectketamine
dc.subjectmethylcellulose
dc.subjectmitomycin
dc.subjectoxybuprocaine
dc.subjectphenylephrine
dc.subjectretinoic acid
dc.subjectsiklomid
dc.subjectthiopental
dc.subjecttropicamide
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcataract
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectcornea edema
dc.subjectdose response
dc.subjectdrug efficacy
dc.subjectepithelium cell
dc.subjectintraoperative period
dc.subjectlens epithelium
dc.subjectnonhuman
dc.subjectphacoemulsification
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectrandomization
dc.titlePrevention of posterior capsule opacification by retinoic acid and mitomycin
dc.typeArticle

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