In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica

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dc.contributor.authorCan, H
dc.contributor.authorKayalar, H
dc.contributor.authorBozkurt, B
dc.contributor.authorCan, S
dc.contributor.authorDöskaya, M
dc.contributor.authorTöz, S
dc.date.accessioned2024-07-18T12:03:07Z
dc.date.available2024-07-18T12:03:07Z
dc.description.abstractComplex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was obtained with methanol extract (at a dose of 50 mu g/ml). In conclusion, S. spinosum may be a potential source for the development of novel therapeutic agents to treat L. tropica infection.
dc.identifier.issn1300-0861
dc.identifier.other1308-2817
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8902
dc.language.isoEnglish
dc.publisherANKARA UNIV PRESS
dc.subjectPLANTS
dc.subjectPROMASTIGOTES
dc.subjectAMASTIGOTES
dc.subjectMECHANISM
dc.titleIn vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica
dc.typeArticle

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