Systemic inflammatory response during cardiopulmonary bypass: Axial flow versus radial flow oxygenators
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Date
2022
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Abstract
Background: The objective of this study was to investigate the inflammatory effects of different oxygenator flow pattern types in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Methods: We designed this randomized, single-blind, prospective study of patients with coronary artery disease. We compared the systemic inflammatory effects of oxygenators with two types of flow: axial flow and radial flow. Therefore, we divided the patients into two groups: 24 patients in the axial group and 28 patients in the radial group. IL-1, IL-6, IL-10, and TNF-α were examined for cytokine activation leading to a systemic inflammatory reaction. The samples were collected at three different time intervals: T1, T2, and T3 (T1 was taken before cardiopulmonary bypass, T2 just 1 h after CPB onset, and T3 was taken 24 h after the surgery). Results: There were no significant differences in demographic characteristics between the two groups. We observed that there were notably lower levels of humoral inflammatory response parameters (IL-1, IL-6, and TNF-α) in the radial flow oxygenator group than in the axial flow group at the specific sampling times. For IL-10, there was no significant difference for any time period. Conclusion: It might be advantageous to use a radial-flow-patterned oxygenator to limit the inflammatory response triggered by the oxygenators in cardiopulmonary bypass. © The Author(s) 2022.
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Keywords
Cardiopulmonary Bypass , Humans , Oxygenators , Prospective Studies , Single-Blind Method , Systemic Inflammatory Response Syndrome , Axial flow , Cardiovascular surgery , Diseases , Flow patterns , anesthetic agent , biological marker , C reactive protein , cytokine , interleukin 1 , interleukin 10 , interleukin 6 , procalcitonin , tumor necrosis factor , Cardiac-surgery , Cardiopulmonary bypass , Coronary artery bypass graft , Coronary artery disease , Flow type , Inflammatory response , Oxygenator flow type , Prospective study , Systemic inflammatory response , TNF α , adult , anticoagulation , artery catheterization , Article , biochemical analysis , blood sampling , cardiopulmonary bypass , cardiopulmonary bypass time , clinical article , clinical trial , controlled study , coronary artery bypass graft , coronary artery disease , data analysis , electrochemiluminescence , enzyme linked immunosorbent assay , erythrocyte , EuroSCORE , female , human , hypothermia , immunoturbidimetry , inflammation , leukocyte , male , platelet count , randomized controlled trial , single blind procedure , venous blood , adverse event , oxygenator , prospective study , systemic inflammatory response syndrome , Radial flow