Systemic inflammatory response during cardiopulmonary bypass: Axial flow versus radial flow oxygenators

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dc.contributor.authorYildirim F.
dc.contributor.authorAmanvermez Senarslan D.
dc.contributor.authorYersel S.
dc.contributor.authorBayram B.
dc.contributor.authorTaneli F.
dc.contributor.authorTetik O.
dc.date.accessioned2024-07-22T08:04:40Z
dc.date.available2024-07-22T08:04:40Z
dc.date.issued2022
dc.description.abstractBackground: The objective of this study was to investigate the inflammatory effects of different oxygenator flow pattern types in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Methods: We designed this randomized, single-blind, prospective study of patients with coronary artery disease. We compared the systemic inflammatory effects of oxygenators with two types of flow: axial flow and radial flow. Therefore, we divided the patients into two groups: 24 patients in the axial group and 28 patients in the radial group. IL-1, IL-6, IL-10, and TNF-α were examined for cytokine activation leading to a systemic inflammatory reaction. The samples were collected at three different time intervals: T1, T2, and T3 (T1 was taken before cardiopulmonary bypass, T2 just 1 h after CPB onset, and T3 was taken 24 h after the surgery). Results: There were no significant differences in demographic characteristics between the two groups. We observed that there were notably lower levels of humoral inflammatory response parameters (IL-1, IL-6, and TNF-α) in the radial flow oxygenator group than in the axial flow group at the specific sampling times. For IL-10, there was no significant difference for any time period. Conclusion: It might be advantageous to use a radial-flow-patterned oxygenator to limit the inflammatory response triggered by the oxygenators in cardiopulmonary bypass. © The Author(s) 2022.
dc.identifier.DOI-ID10.1177/03913988221075043
dc.identifier.issn03913988
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12779
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.subjectCardiopulmonary Bypass
dc.subjectHumans
dc.subjectOxygenators
dc.subjectProspective Studies
dc.subjectSingle-Blind Method
dc.subjectSystemic Inflammatory Response Syndrome
dc.subjectAxial flow
dc.subjectCardiovascular surgery
dc.subjectDiseases
dc.subjectFlow patterns
dc.subjectanesthetic agent
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectcytokine
dc.subjectinterleukin 1
dc.subjectinterleukin 10
dc.subjectinterleukin 6
dc.subjectprocalcitonin
dc.subjecttumor necrosis factor
dc.subjectCardiac-surgery
dc.subjectCardiopulmonary bypass
dc.subjectCoronary artery bypass graft
dc.subjectCoronary artery disease
dc.subjectFlow type
dc.subjectInflammatory response
dc.subjectOxygenator flow type
dc.subjectProspective study
dc.subjectSystemic inflammatory response
dc.subjectTNF α
dc.subjectadult
dc.subjectanticoagulation
dc.subjectartery catheterization
dc.subjectArticle
dc.subjectbiochemical analysis
dc.subjectblood sampling
dc.subjectcardiopulmonary bypass
dc.subjectcardiopulmonary bypass time
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled study
dc.subjectcoronary artery bypass graft
dc.subjectcoronary artery disease
dc.subjectdata analysis
dc.subjectelectrochemiluminescence
dc.subjectenzyme linked immunosorbent assay
dc.subjecterythrocyte
dc.subjectEuroSCORE
dc.subjectfemale
dc.subjecthuman
dc.subjecthypothermia
dc.subjectimmunoturbidimetry
dc.subjectinflammation
dc.subjectleukocyte
dc.subjectmale
dc.subjectplatelet count
dc.subjectrandomized controlled trial
dc.subjectsingle blind procedure
dc.subjectvenous blood
dc.subjectadverse event
dc.subjectoxygenator
dc.subjectprospective study
dc.subjectsystemic inflammatory response syndrome
dc.subjectRadial flow
dc.titleSystemic inflammatory response during cardiopulmonary bypass: Axial flow versus radial flow oxygenators
dc.typeArticle

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