Evaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease

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dc.contributor.authorUzunoglu, S
dc.contributor.authorAcar, H
dc.contributor.authorOkudan, N
dc.contributor.authorGökbel, H
dc.contributor.authorMevlitoglu, I
dc.contributor.authorSari, F
dc.date.accessioned2024-07-18T11:52:08Z
dc.date.available2024-07-18T11:52:08Z
dc.description.abstractGlutathione S-transferases (GST) play an important role in oxidative stress related syndromes. An imbalance of the oxidant and antioxidant systems is important in the pathogenesis of Behcet's disease (BD). The objective of this study was to evaluate the association of null genotypes of GST-M1 and GST-T1 with BD since some preliminary molecular genetic data were recently published. Ninety-four Turkish BD patients (42 male, 52 female, 37.1 +/- 10.4 years) and 140 healthy volunteers (70 male, 70 female, 36.8 +/- 11.7 years) matched for age and gender with the patients as the control group were included in the study. Distributions of GST-M1 and GST-T1 genotypes were determined by multiplexed PCR using three sets of primers for GST-M1, GST-T1, and beta-globulin genes. There was no association between BD and the frequencies of GST-M1 and GST-T1 null genotypes when compared to controls by separate analysis. However, by cross and pooled combination analysis there was a significant association between the frequencies of pooled GSTs with one or both null genotypes in BD and controls. This is the first evidence that the association between the frequencies of GST-M1 and GST-T1 null genotypes and BD might be dependent on the interaction of multiple null allele polymorphisms rather than a single null allele of GST-M1 and GST-T1.
dc.identifier.issn0340-3696
dc.identifier.other1432-069X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5395
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectANTIOXIDANT ENZYME-ACTIVITIES
dc.subjectOXIDATIVE STRESS
dc.subjectTURKISH POPULATION
dc.subjectBREAST-CANCER
dc.subjectNITRIC-OXIDE
dc.subjectPOLYMORPHISMS
dc.subjectM1
dc.subjectSUSCEPTIBILITY
dc.subjectDAMAGE
dc.titleEvaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease
dc.typeArticle

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