Browsing by Subject "tramadol"

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    The effect of tramadol on minimal alveolar enflurane concentrations in children; [TRAMADOL'UN COCUKLARDA MINIMAL ALVEOLER ENFLURAN KONSANTRASYONLARINA ETKISI]
    (1996) Erincler T.
    Laryngospasm following extubation can be quite troublesome after adenoidectomy and tonsillectomy for children. High end-tidal anesthetic concentrations may prevent the anesthetized patients from coughing or moving during and immediately after tracheal extubation, but extubating while the child is quite deeply anesthetized is uncommon in current practice. In this study it has been proved that tramadol given intravenously at a dose of 2 mg/kg following extubation is quite effective in preventing laryngospasm in children after adenoidectomy, and does not cause respiratory depression. Eighty-seven children undergoing adenoidectomy and myringotomy were divided randomly into two groups consisting of 33 and 54 children. Tramadol was given intravenously after the induction of anesthesia to the larger group. Anesthesia was maintained with enflurane, nitrous oxide and oxygen in both groups. End-tidal enflurane concentrations were sampled from a -T- piece attached to the endotracheal tube and measured continuously by mass spectrometry. Oxygen saturations were monitored by pulse oximetry. The minimum alveolar concentrations of enflurane for satisfactory tracheal extubation were found to be 1.9 ± 0.5% and 0.8 ± 0.4% in group I and group II children, respectively. In anesthetized children between ages 2 and 9, tracheal extubation may be accomplished without coughing, laryngospasm or respiratory depression with smaller end-tidal enflurane concentrations, if tramadol is administered previously.
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    The addition of metoclopramide to the PCA with tramadol; [Tramadol ile yapilan PCA'ya metoklopramid eklenmesi]
    (1998) Luleci N.; Erincler T.; Tekin I.; Gumus B.; Erbuyun K.; Tutan A.
    Nausea and vomiting is a major problem during opioid administrations. In PCA (Patient Controlled Analgesia), sufficient analgesia can be obtained with smaller doses of opioids but nause and vomiting may still a great problem. Addition of antiemetics to opioids in PCA applications is not studied adequately. In this study we added metoclopramide to tramadol hydrochloride (TH) TH for PCA and evaluated its effects on the nausea and vomiting. 36 patients in ASA I-III, were allocated randomly into two groups (each had 18 patients) to receive patient-controlled analgesia with either TH and metoclopramide combination or with TH alone. Bolus doses of TH 20 mg (limited to 200 mg in four hours) alone used in the first and combined with metoclopramide 5 mg in the second group were used with a lockout time of 15 min. During the first 24 h. after surgery the VAS scores and side effects were recorded. The patients in metoclopramide group have significantly lower PAC scores (p<0.05). As a result nausea and vomiting can be reduced by addition of metoclopramide to TH in PCA. The same method maybe used also with of other opioids.
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    Subanalgesic Dose of Ketamine Added to Tramadol Does Not Reduce Analgesic Demand; [Tramadole, Subanaljezik Dozda Ketamin İlavesi Analjezik Gereksinimini Azaltmiyor]
    (2004) Yentür E.A.; Topçu I.; Keleş G.T.; Taşyüz T.; Sakarya M.
    Tramadol is an analgesic with agonistic properties on opioid receptors. In this study we investigated the effect of systemic coadministration of subanalgesic dose of ketamine with tramadol on postoperative tramadol consumption. By this way we intended to find a clue whether tramadol also have opioid induced algesic effect like morphine via NMDA receptors. Thirty patients undergoing abdominal surgery with general anesthesia were enrolled in this prospective, placebo controlled, double blind study. Anesthesia was induced with propofol 2-2.5 mg kg-1 and was maintained with sevoflurane in N2O/O2 mixture. Muscle relaxation was provided by vecuronium. Analgesia was maintained by iv remifentanyl infusion. Infusion of remifentanyl was stopped 15 min before the end of operation, and 10 min later patients were randomly administered either 75 mg kg-1 ketamine (5 mL) and 1 mg kg-1 tramadol (ketamin group) or normal saline (5 ml) and 1 mg kg-1 tramadol bolus (placebo group). Intravenous PCA with tramadol was started on the arrival at postoperative recovery room, and continued for 24 hours in all patients. Pain and sedation scores were evaluated in the recovery room every 15 min until the time of discharge to the ward. Aldrete Post Anesthesia Recovery Scores (≥9) were used as discharge criteria. Total tramadol consumptions at the 6th and 24th hours were recorded. There was no significant difference between the groups with respect to Visual Analog Scale (6.1±1.1 vs 6.6±1.1) and total tramadol consumption (51.5±26.4 vs 53.7±18.3 mg) at the end of recovery period (p>0.05). Also the total tramadol consumptions at 6th and 24th hours (188.9±82.9 vs 215.3±104.7 and 365.0±118.6 vs 403.8±243.8 respectively) were not different between groups (p>0.05). Subanalgesic dose of ketamine did not augment tramadol induced analgesia so these findings may suggest that tramadol does not have NMDA receptor activating property like morphine.
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    The effects of tramadol and fentanyl on gastrointestinal motility in septic rats
    (Lippincott Williams and Wilkins, 2006) Topcu I.; Ekici N.Z.; Isik R.; Sakarya M.
    In this study, we investigated the effects of tramadol and fentanyl on gastrointestinal transit (GIT) during acute systemic inflammation in an experimental model of cecal ligation and perforation (CLP). One-hundred-twenty male Swiss-Albino rats were divided randomly into 6 groups: Group I = sham-operated + saline; Group II = sham-operated + fentanyl; Group III = sham-operated + tramadol; Group IV = CLP + saline; Group V = CLP + fentanyl; Group VI = CLP + tramadol. Suspension of charcoal was administered as an intragastric meal to measure the GIT. GIT% (mean ± SD) were 46.1% ± 9.8%, 43.2% ± 9.8%, 45.9% ± 10.2%, 33.2% ± 9.2%, 24.9% ± 4.1%, and 31.8% ± 8.4% in Groups I, II, III, IV, V, and VI, respectively. GIT% was significantly less in Group V than in Groups I, II, III, and IV (P < 0.05). The Group VI mean value was significantly lower than those of Groups I, II, and III (P < 0.05) but not different from those of Groups IV and V (P > 0.05). The antitransit effect of fentanyl was shown to have increased in the experimental sepsis model, but no decrease in GIT was obtained with tramadol. This was thought to be the result of an associated endogenic opioid system activation and receptor upregulation in sepsis. ©2006 by the International Anesthesia Research Society.
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    Unusual long bone and metacarpo-carpal abnormalities in a case of pseudo-pseudohypoparathyroidism
    (2007) Unlu Z.; Orguc S.; Yilmaz Ovali G.; Bayindir P.
    A case of pseudo-pseudohypoparathyroidism (PPH) with shortening of the left femur and tibia and coalition of the base of the fourth metacarpals with capitatum and hamatum in bilateral wrist joints was presented. Involvement of the fourth digits both in hands and feet were more prominent on the left side, with shortening of the left leg. © Clinical Rheumatology 2006.
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    The effects of tramadol on cancer stem cells and metabolic changes in colon carcinoma cells lines
    (Elsevier B.V., 2019) Özgürbüz U.; Gencür S.; Kurt F.Ö.; Özkalkanlı M.; Vatansever H.S.
    Opioids are widely used in the treatment of cancer related pain. They mainly exert their effects on opioid receptors. The most common opioid in the treatment of pain is morphine. Previous studies show that they may have effects on cancer cell behavior. These may include apoptosis, angiogenesis, invasion, inflammation and immune reactions. Tramadol, also an opioid is widely used in the treatment of cancer pain and is not well studied in cancer behavior. We aimed to investigate the effects of tramadol on cancer stem cells and metabolic changes in colon carcinoma cells. We used Colo320 (ATCC, CCL-220), Colo741 (ECACC, 93052621) and HCT116 (ATCC, CCL-247) colon cancer cell lines. CD133 was considered colon cancer stem cell marker and used to sort CD133+ and CD133− cells by magnetic cell sorting. MTT (mitochondria-targeted therapeutics) technique was used to detect tramadol's cytotoxic effect on cells in the study groups. Cells were treated with 1 mg/kg, 1.5 mg/kg and 2 mg/kg tramadol for 24 h at 37 °C and 5% CO2.Caspase-3, Ki-67, Bcl-2 and VGEF distributions were performed using indirect immunoperoxidase staining for immunohistochemical analysis. The study showed that tramadol has triggering effect on apoptosis in Colo320 colon cancer stem cells. © 2019 Elsevier B.V.
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    Comparison of Postoperative Analgesic Efficacy of Different Methods after Cesarean-Section; [Sezaryen Sonrası Farklı Yöntemlerin Arasında Postoperatif Analjezik Etkinliğin Karşılaştırılması]
    (Anestezi Dergisi, 2020) Ok G.; Çevikkalp E.; Ülkümen B.A.; Erbüyün K.; Hasdemir P.S.; Özyurt B.C.; Aydın D.
    Objective: In this research study,we compared postoperative analgesic effects of general anesthesia followed with transversus abdominis plane block (TAPB), epidural or spinal anesthesia and we aimed to figure out the efficacy of TAPB for the postoperative pain. Method: After approval of the ethics committee (date: 03.25.2015; decision no: 142) for the study was obtained, the study population scheduled for elective cesarean operations was divided in three subgroups as spinal, epidural and general anesthesia. Group T consisted of 30 cases that underwent general anesthesia and TAP; Group E consisted of 32 cases that underwent epidural anesthesia; and Group S consisted of 30 cases that underwent spinal anesthesia. All cases received 75 mg IM diclophenac sodium after the operation. Data about the postoperative pain (the onset time of the pain, and the severity of the pain evaluated with VAS (Visual Analog Scale) and the need for adjuvant analgesics) were recorded. In addition, heart rate, blood pressure, peripheric oxygen saturation, respiration rates at postoperative 0., 1., 4., 6. and 12. hours and side effects seen were recorded. If the patient needed any additional postoperative analgesics, 50 mg tramadol was injected intravenously. Results: There was no significant difference between the groups regarding postoperative analgesia need (Table II). The need for postoperative tramadol was minimum for patients in Group E and maximum for patients in Group S (p<0.05). VAS scores at postoperative 0., 1. and 6. hours were significantly lower for patients in Group E (p<0,05). Regarding the groups T and S, VAS scores at 6. hours were significantly lower in Group T when compared with Group S (p<0.05). Conclusion: We found that the efficacy of the epidural anesthesia was more prominent and the best method for decreasing postoperative consumption of tramadol. Epidural anesthesia increased the postoperative analgesic efficacy and decreased the tramadol consumption in patients undergoing TAP block. In order to increase the comfort of the mother and newborn, TAPB may be an option for patients who are not candidates for epidural anaesthesia. © Copyright Anesthesiology and Reanimation Specialists’ Society.
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    Evaluation of the physical and emotional effects of the COVID-19 pandemic on patients with fibromyalgia and chronic low back pain: A multicenter cross-sectional controlled study
    (Turkish Society of Physical Medicine and Rehabilitation, 2022) Bagcier F.; Kibar S.; Evcik D.; Ketenci A.; Sindel D.; Tur B.S.; Ünlü Z.; Tıkız C.; Keskin D.; Alp A.; Ay S.; Yanık B.; Külcü D.G.; Karakaş M.; Ural Nazlıkul F.G.; Kurt Oktay K.N.; Aksoy M.K.; Fındıkoğlu G.; Eser F.; Atıcı A.; Yurdakul O.V.; Koçak F.A.; Kurt E.E.; Özkan Y.; Doğan Ş.K.; Sultanoğlu T.E.; Ordahan B.; Umay E.K.; Demirhan E.; Yağcı H.Ç.; Balbaloğlu Ö.; Tezel N.; Satış S.; Atar S.; Akaltun M.S.
    Objectives: This study aimed to investigate the physical and emotional effects of the coronavirus disease 2019 pandemic in patients with fibromyalgia syndrome (FMS) and chronic low back pain (CLBP) patients. Patients and methods: The cross-sectional controlled study was performed with 1,360 participants (332 males, 1,028 females; mean age: 42.3±12.5 years; range, 18 to 65 years) between September 2020 and February 2021. The participants were evaluated in three groups: the FMS group (n=465), the CLBP group (n=455), and the healthy control group (n=440). Physical activity, pain levels, and general health status before and during the pandemic were evaluated in all participants. Stress levels were analyzed with the perceived stress scale (PSS) in all groups, and disease activity was analyzed with the fibromyalgia impact questionnaire (FIQ) in patients with FMS. Results: Patients with FMS had worsened general health status and pain levels during the pandemic compared to the other groups (p<0.01). The FMS group showed significantly higher PSS scores than those in other groups (p<0.01). There was a weak-positive correlation between FIQ and PSS parameters in patients with FMS (p<0.05, r=0.385). Conclusion: The general health status, pain, and stress levels of the patients with FMS and CLBP tended to worsen during the pandemic. This high-stress level appeared to affect disease activity in patients with FMS. ©2022 All right reserved by the Turkish Society of Physical Medicine and Rehabilitation.
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    A comparison of the effects of thoracolumbar interfascial plane (TLIP) block and erector spinae plane (ESP) block in postoperative acute pain in spinal surgery
    (Springer Science and Business Media Deutschland GmbH, 2024) Dilsiz P.; Sari S.; Tan K.B.; Demircioğlu M.; Topçu İ.; Erel V.K.; Aydin O.N.; Turgut M.
    Purpose: Spinal surgeries are a very painful procedure. New regional techniques for postoperative pain management are being considered. The present study aimed to evaluate the hypothesis that the ultrasound-guided erector spinae plane (ESP) block would lead to lower opioid consumption compared to the thoracolumbar interfascial plane (TLIP) block after lumbar disk surgery. The study's primary objective was to compare postoperative total opioid consumption, and the secondary objective was to assess postoperative pain scores. Methods: Sixty-eight patients who underwent elective lumbar disk surgery were randomly assigned to either the ESP block group or the TLIP block group. The current pain status of the patients in both the ESP and TLIP block groups was assessed using the Numerical Rating Scale (NRS) at specific time intervals (30 min, 1, 6, 12 and 24 h) during the postoperative period. The number of times patients administered a bolus dose of patient-controlled analgesia, (PCA) within the first 24 h was recorded. Results: In the ESP group, the total opioid consumption in terms of morphine equivalents was found to be significantly lower (ESP group: 7.7 ± 7.0; TLIP group: 13.0 ± 10.1; p < 0.05). The NRS scores were similar between the groups at 30 min, 1, 6, and 12 h, but at 24 h, they were significantly lower in the ESP group. Moreover, the groups had no significant difference regarding observed side effects. Conclusion: This study demonstrated the analgesic efficacy of both techniques, revealing that the ESP block provides more effective analgesia in patients undergoing lumbar disk surgery. © The Author(s) 2024.