Investigation of the Protective Effects of Acetyl L-Carnitine on Cisplatin-Induced Uterus Toxicity

Sermin SEYHAN; GÜLİSTAN SANEM SARIBAŞ; Neslihan COŞKUN AKÇAY; SEREN GÜLŞEN GÜRGEN; Seda Nur AKYOL; GÜLESER GÖKTAŞ; İbrahim Murat HIRFANOĞLU; Deniz ERDOĞAN; Candan ÖZOĞUL

Investigation of the Protective Effects of Acetyl L-Carnitine on Cisplatin-Induced Uterus Toxicity

Date

2018

Authors

Sermin SEYHAN

GÜLİSTAN SANEM SARIBAŞ

Neslihan COŞKUN AKÇAY

SEREN GÜLŞEN GÜRGEN

Seda Nur AKYOL

GÜLESER GÖKTAŞ

İbrahim Murat HIRFANOĞLU

Deniz ERDOĞAN

Candan ÖZOĞUL

Abstract

Objective: The aim of the study was to investigate the prophylactic effects ofacetyl L-carnitine against to uterus induced by cisplatin.Methods: Twenty-four female Wistar albino rats were divided into four groups:group I (control) was administered with saline; group II was administered withacetyl L-carnitine; group III was administered with cisplatin; group IV waspretreated with acetyl L-carnitine before cisplatin intraperitoneal injection. After72h of cisplatin injection uterine tissue was removed. Histological andimmunohistochemical investigations were performed, respectively.Results: We found that the number of TUNEL and caspases positive cells wereincreased in the endometrial epithelium, subepithelial connective tissue,endometrial glands and stroma in group III compare to the other groups.Furthermore inflammation and edema were observed in uterus of rats in groupIII.Conclusion: We can concluded that pretreatment of acetyl L-carnitineadministration has protective effect on histological alteration of uterus causedby cisplatin.