Investigation of the Protective Effects of Acetyl L-Carnitine on Cisplatin-Induced Uterus Toxicity

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dc.contributor.authorSermin SEYHAN
dc.contributor.authorGÜLİSTAN SANEM SARIBAŞ
dc.contributor.authorNeslihan COŞKUN AKÇAY
dc.contributor.authorSEREN GÜLŞEN GÜRGEN
dc.contributor.authorSeda Nur AKYOL
dc.contributor.authorGÜLESER GÖKTAŞ
dc.contributor.authorİbrahim Murat HIRFANOĞLU
dc.contributor.authorDeniz ERDOĞAN
dc.contributor.authorCandan ÖZOĞUL
dc.date.accessioned2024-07-24T09:13:35Z
dc.date.available2024-07-24T09:13:35Z
dc.date.issued2018
dc.description.abstractObjective: The aim of the study was to investigate the prophylactic effects ofacetyl L-carnitine against to uterus induced by cisplatin.Methods: Twenty-four female Wistar albino rats were divided into four groups:group I (control) was administered with saline; group II was administered withacetyl L-carnitine; group III was administered with cisplatin; group IV waspretreated with acetyl L-carnitine before cisplatin intraperitoneal injection. After72h of cisplatin injection uterine tissue was removed. Histological andimmunohistochemical investigations were performed, respectively.Results: We found that the number of TUNEL and caspases positive cells wereincreased in the endometrial epithelium, subepithelial connective tissue,endometrial glands and stroma in group III compare to the other groups.Furthermore inflammation and edema were observed in uterus of rats in groupIII.Conclusion: We can concluded that pretreatment of acetyl L-carnitineadministration has protective effect on histological alteration of uterus causedby cisplatin.
dc.identifier.issn1300-056X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/25410
dc.language.isoeng
dc.titleInvestigation of the Protective Effects of Acetyl L-Carnitine on Cisplatin-Induced Uterus Toxicity
dc.typeAraştırma Makalesi

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