THE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY
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Abstract
Objective: The aim of this study is to investigate how acute hyperglycaemic changes affect the choroid in patients with prediabetes. Material and Method: Each subject underwent a 75 g oral glucose tolerance test (OGTT) after overnight fasting. The measurement of choroidal thickness (ChT) was done with new generation spectral domain optical coherence tomography (SD-OCT). Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p<0.0001). Mean insulin levels were also higher in patients with prediabetes than in healthy volunteers during the entire experiment (all p<0.0001). Changes in ChT differed between the groups, a transient increase was observed in the mean ChT as well as subfoveal, nasal and temporal locations at the 500 mu m distance to fovea in prediabetes individuals. While the subfoveal ChT difference was 1.52 +/- 4.11 mu m (range, -11.00/24.00 mu m) in prediabetes, -0.22 +/- 1.74 mu m (range -2.00/8.00 mu m) in the con- trol group at the first hour of the OGTT. A transient choroidal thickening occurred in the prediabetes group, while there was no change in the healthy volunteers. Conclusion: Detecting acute hyperglycemic changes with instant measurements may help us to better understand the effect of the disease on ocular structures.