THE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY

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dc.contributor.authorÇagiltay, E
dc.contributor.authorAltinisik, M
dc.contributor.authorPouwels, S
dc.contributor.authorDemir, N
dc.contributor.authorAkay, F
dc.date.accessioned2024-07-18T12:03:24Z
dc.date.available2024-07-18T12:03:24Z
dc.description.abstractObjective: The aim of this study is to investigate how acute hyperglycaemic changes affect the choroid in patients with prediabetes. Material and Method: Each subject underwent a 75 g oral glucose tolerance test (OGTT) after overnight fasting. The measurement of choroidal thickness (ChT) was done with new generation spectral domain optical coherence tomography (SD-OCT). Results: Fasting Plasma Glucose (FPG) levels of the patients with only isolated Impaired Fasting Glucose (IGT) patients are higher (all p<0.0001). Mean insulin levels were also higher in patients with prediabetes than in healthy volunteers during the entire experiment (all p<0.0001). Changes in ChT differed between the groups, a transient increase was observed in the mean ChT as well as subfoveal, nasal and temporal locations at the 500 mu m distance to fovea in prediabetes individuals. While the subfoveal ChT difference was 1.52 +/- 4.11 mu m (range, -11.00/24.00 mu m) in prediabetes, -0.22 +/- 1.74 mu m (range -2.00/8.00 mu m) in the con- trol group at the first hour of the OGTT. A transient choroidal thickening occurred in the prediabetes group, while there was no change in the healthy volunteers. Conclusion: Detecting acute hyperglycemic changes with instant measurements may help us to better understand the effect of the disease on ocular structures.
dc.identifier.other1305-6441
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9084
dc.language.isoEnglish
dc.publisherISTANBUL UNIV, FAC MEDICINE, PUBL OFF
dc.subjectRETINAL BLOOD-FLOW
dc.subjectFOVEAL AVASCULAR ZONE
dc.subjectDIABETIC-RETINOPATHY
dc.subjectOXYGEN-SATURATION
dc.subjectACUTE HYPERGLYCEMIA
dc.subjectINSULIN
dc.subjectEYES
dc.subjectCHOROIDOPATHY
dc.subjectREFRACTION
dc.subjectSEVERITY
dc.titleTHE MEASUREMENT OF THE CHOROIDAL THICKNESS DURING ORAL GLUCOSE TOLERANCE TESTS IN PREDIABETIC SUBJECTS: A SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY
dc.typeArticle

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