Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles

Türkkanı G.; Güngör B.; Cetin O.; İçhedef Ç.; Parlak Y.; Gümüşer F.G.; Sayıt Bilgin B.E.; Teksöz S.

Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles

Date

2023

Authors

Publisher

Springer Science and Business Media B.V.

Abstract

In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. Graphical abstract: [Figure not available: see fulltext.] © 2023, Akadémiai Kiadó, Budapest, Hungary.