Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles
| dc.contributor.author | Türkkanı G. | |
| dc.contributor.author | Güngör B. | |
| dc.contributor.author | Cetin O. | |
| dc.contributor.author | İçhedef Ç. | |
| dc.contributor.author | Parlak Y. | |
| dc.contributor.author | Gümüşer F.G. | |
| dc.contributor.author | Sayıt Bilgin B.E. | |
| dc.contributor.author | Teksöz S. | |
| dc.date.accessioned | 2025-04-10T11:03:10Z | |
| dc.date.available | 2025-04-10T11:03:10Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. Graphical abstract: [Figure not available: see fulltext.] © 2023, Akadémiai Kiadó, Budapest, Hungary. | |
| dc.identifier.DOI-ID | 10.1007/s10967-023-08975-5 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/44551 | |
| dc.publisher | Springer Science and Business Media B.V. | |
| dc.title | Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles | |
| dc.type | Article |