Toll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD

Gürol Şahin ULUTAŞ; Aylin ÖZGEN ALPAYDIN; Fatma TANELİ; Cemile ÇETİNKAYA; Cevval ULMAN; YEŞİM GÜVENÇ DEMİRAĞCI; Gönül Dinç HORASAN; Ayşın Şakar COŞKUN

Toll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD

Date

2014

Authors

YEŞİM GÜVENÇ DEMİRAĞCI

Gönül Dinç HORASAN

Ayşın Şakar COŞKUN

Abstract

as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients.MATerIAL ANd MeTHods: Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR-2 expression were measured by flow cytometry in the whole study population.resULTs: No significant difference was observed in TLR-2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV1/FVC were found to have a mild positive correlation (r=0.295, p=0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=-0.274, p=0.034).CoNCLUsIoN: We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR-2 expression of CD14+ monocytes in patients with airway obstruction.