Toll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD

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dc.contributor.authorGürol Şahin ULUTAŞ
dc.contributor.authorAylin ÖZGEN ALPAYDIN
dc.contributor.authorFatma TANELİ
dc.contributor.authorCemile ÇETİNKAYA
dc.contributor.authorCevval ULMAN
dc.contributor.authorYEŞİM GÜVENÇ DEMİRAĞCI
dc.contributor.authorGönül Dinç HORASAN
dc.contributor.authorAyşın Şakar COŞKUN
dc.date.accessioned2024-07-24T09:09:00Z
dc.date.available2024-07-24T09:09:00Z
dc.date.issued2014
dc.description.abstractas well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients.MATerIAL ANd MeTHods: Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR-2 expression were measured by flow cytometry in the whole study population.resULTs: No significant difference was observed in TLR-2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV1/FVC were found to have a mild positive correlation (r=0.295, p=0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=-0.274, p=0.034).CoNCLUsIoN: We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR-2 expression of CD14+ monocytes in patients with airway obstruction.
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/21747
dc.language.isoeng
dc.subject[Fen > Tıp > Solunum Sistemi, Fen > Tıp > Kulak, Burun, Boğaz]
dc.titleToll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD
dc.typeAraştırma Makalesi

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