Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

Mesut METE; Işıl AYDEMİR; Ülkün Ünlü ÜNSAL; Fatih ÇÖLLÜ; Gokhan VATANDAS; BEYHAN GÜRCÜ; Yusuf Kurtuluş DURANSOY; Fatma TANELİ; Mehmet İbrahim TUĞLU; Mehmet SELÇUKİ

Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

Date

2018

Authors

Yusuf Kurtuluş DURANSOY

Fatma TANELİ

Mehmet İbrahim TUĞLU

Mehmet SELÇUKİ

Abstract

AIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP)twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group,brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemicalmethods.RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findingsdemonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4.CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress andapoptosis.