Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

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dc.contributor.authorMesut METE
dc.contributor.authorIşıl AYDEMİR
dc.contributor.authorÜlkün Ünlü ÜNSAL
dc.contributor.authorFatih ÇÖLLÜ
dc.contributor.authorGokhan VATANDAS
dc.contributor.authorBEYHAN GÜRCÜ
dc.contributor.authorYusuf Kurtuluş DURANSOY
dc.contributor.authorFatma TANELİ
dc.contributor.authorMehmet İbrahim TUĞLU
dc.contributor.authorMehmet SELÇUKİ
dc.date.accessioned2024-07-24T09:13:32Z
dc.date.available2024-07-24T09:13:32Z
dc.date.issued2018
dc.description.abstractAIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP)twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group,brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemicalmethods.RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findingsdemonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4.CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress andapoptosis.
dc.identifier.DOI-ID10.5137/1019-5149.JTN.21417-17.2
dc.identifier.issn1019-5149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/25375
dc.language.isoeng
dc.subject[Fen > Tıp > Cerrahi]
dc.titleNeuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury
dc.typeAraştırma Makalesi

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