Toll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD
No Thumbnail Available
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
OBJECTIVES : We aimed to evaluate toll- like receptor 2 (TLR- 2) expression on monocytes and peripheral blood CD4+/CD8+ T cell ratio, as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients. MATERIAL AND METHODS : Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR- 2 expression were measured by flow cytometry in the whole study population. RESULTS : No significant difference was observed in TLR- 2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV 1 /FVC were found to have a mild positive correlation (r= 0.295, p= 0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=- 0.274, p= 0.034). CONCLUSION : We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR- 2 expression of CD14+ monocytes in patients with airway obstruction.