Toll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD

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dc.contributor.authorUlutas, GS
dc.contributor.authorAlpaydin, AÖ
dc.contributor.authorTaneli, F
dc.contributor.authorÇetinkaya, C
dc.contributor.authorUlman, C
dc.contributor.authorGüvenç, Y
dc.contributor.authorHorasan, GD
dc.contributor.authorCoskun, AS
dc.date.accessioned2024-07-18T12:05:02Z
dc.date.available2024-07-18T12:05:02Z
dc.description.abstractOBJECTIVES : We aimed to evaluate toll- like receptor 2 (TLR- 2) expression on monocytes and peripheral blood CD4+/CD8+ T cell ratio, as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients. MATERIAL AND METHODS : Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR- 2 expression were measured by flow cytometry in the whole study population. RESULTS : No significant difference was observed in TLR- 2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV 1 /FVC were found to have a mild positive correlation (r= 0.295, p= 0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=- 0.274, p= 0.034). CONCLUSION : We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR- 2 expression of CD14+ monocytes in patients with airway obstruction.
dc.identifier.issn1302-7808
dc.identifier.other1308-5387
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9489
dc.language.isoEnglish
dc.publisherAVES
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectLYMPHOCYTE SUBSETS
dc.subjectSMOOTH-MUSCLE
dc.subjectTOLL-LIKE-RECEPTOR-2
dc.subjectACTIVATION
dc.subjectRESPONSIVENESS
dc.subjectINFLAMMATION
dc.subjectMACROPHAGES
dc.subjectMONOCYTES
dc.subjectSMOKING
dc.titleToll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD
dc.typeArticle

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